If you are a founder, marketer, or agency lead, your week probably starts inside a spreadsheet. You are cleaning CRM exports, stitching ad data to revenue, and wrestling with columns that never quite line up. Selecting multiple columns sounds trivial until you are doing it across dozens of tabs and files, on desktop and mobile, with different keyboard quirks in Google Sheets and Excel.
In Sheets, you drag headers for adjacent columns, use Ctrl or Cmd for non-adjacent ones, and Shift for ranges. On some Macs, a stray browser plugin even blocks command-click selection, forcing you into tedious workarounds. In Excel, the patterns are similar, but muscle memory does not always transfer. Multiply those tiny frictions by the number of reports your team touches and you have a hidden tax on every campaign.
This is exactly where an AI computer agent becomes strategic. Instead of you remembering every shortcut, the agent can learn your exact selection patterns, repeat them flawlessly across files, and chain them into larger workflows like VLOOKUP setups or ARRAYFORMULA expansions. You stop burning attention on mechanics, and start using Sheets and Excel as decision engines rather than click playgrounds.
Every serious business eventually runs on spreadsheets. A sales leader exporting CRM data, a marketer joining ad spend to revenue, an agency building weekly client reports – all of them live in Google Sheets and Excel. And almost all of them waste time just selecting the right columns before they can do anything useful.
This guide walks through three layers of mastery: manual techniques, no-code automation, and finally AI agents that can operate Sheets and Excel for you at scale.
These are the foundations your AI agent will later mimic.
In Excel (Windows and Mac):
These manual moves are your baseline. They also define the behaviors your AI agent will reproduce.
Once you know the basics, you can start reducing repetitive column selection without writing code.
crm_metrics.These no-code tools move you from repetitive clicking to reusable actions. But they are still bound to a single application and usually one workbook at a time.
Now imagine you are a CMO or agency owner. Every Monday, you or your team:
Here is how an AI agent platform like Simular Pro can handle multi-column selection at scale.
By combining strong manual habits, no-code shortcuts, and AI agents that literally operate Google Sheets and Excel for you, column selection stops being a bottleneck. It becomes just another repeatable step in a larger, reliable workflow that your AI can execute while you focus on strategy, clients, and revenue.
Sometimes you do not just want a block of columns; you want every second one, such as dates in B, D, F and so on. Google Sheets does not have a native pattern-select feature, but you can get there fast with a mix of tricks.
On desktop:
1) Click the first target column header, for example B.
2) Hold Ctrl (Windows/ChromeOS) or Cmd (Mac).
3) While holding, click D, F, H and any other alternate columns you need.
4) Release – all selected columns will now highlight together.
If you need this pattern regularly, save time by using named ranges or macros:
- First, perform the Ctrl/Cmd-click selection once.
- In Sheets, go to Data > Named ranges and name it something like `every_second_column`.
- Next time, reference that range in formulas instead of manually selecting columns.
For more on multi-column operations and shortcuts, check the Google Sheets Help Center: https://support.google.com/docs/
In Excel, the same Ctrl/Cmd-click approach works on column headers, and you can also record a macro while performing the pattern selection and reuse it.
To select non-adjacent columns in Google Sheets on desktop:
1) Click the first column header you want (for example, B).
2) Hold Ctrl on Windows/ChromeOS or Cmd on Mac.
3) While holding, click additional column headers such as E, H, or K.
4) Release the key – all of those columns should remain highlighted.
If this does not work on a Mac, a common cause (reported in Apple Community threads) is a browser extension intercepting the Cmd-click. Troubleshoot by:
- Opening Sheets in an incognito or private window.
- Disabling extensions one by one until Cmd-click works again.
On mobile, Sheets does not fully support non-adjacent column selection. You can tap a header and drag handles to extend a continuous range, but you cannot easily skip columns. For complex selection work, switch to desktop.
Refer to Google Docs Editors Help for device-specific behaviors: https://support.google.com/docs/ and search for keyboard shortcuts and selection tips.
If Ctrl or Cmd click is not letting you select multiple columns in Google Sheets, work through these checks:
1) Are you clicking column headers?
Multi-select only works when you click the letters at the top (A, B, C). Ctrl/Cmd-clicking cells inside the grid will not select entire columns.
2) Are you holding the key the whole time?
You must keep Ctrl (Windows/ChromeOS) or Cmd (Mac) pressed while clicking each additional header. If you release the key too early, the prior selection is cleared.
3) Browser extensions and plugins
On Mac especially, some browser extensions interfere with command-click behavior. As reported in Apple’s support forums, opening Sheets in an incognito window often restores normal selection. If so, disable extensions one at a time until you find the culprit.
4) Try another browser or profile
Test in a different browser (for example, Chrome vs Safari) or a clean profile. If it works there, you know the issue is environmental, not Sheets itself.
If problems persist, consult the Google Docs Editors Help Center at https://support.google.com/docs/ and search for keyboard shortcuts or selection issues.
On mobile, selection is more limited than on desktop, but you can still work efficiently with a few gestures.
In Google Sheets mobile app:
1) Tap a column letter to select the entire column.
2) To expand to adjacent columns, drag the blue selection handles left or right. This lets you span several neighboring columns.
3) Use the toolbar to format, hide, or clear those columns.
Non-adjacent column selection (for example, B and E but not C or D) is not supported in the same way as desktop Ctrl/Cmd-click. For those patterns, switch to a laptop or desktop browser.
In Excel mobile:
1) Tap the column letter to select a full column.
2) Drag the handles to cover adjacent columns.
3) Use the bottom ribbon for formatting or inserting.
When mobile limitations slow you down, a practical pattern is to let an AI agent operate on your desktop: you keep working on strategic review from your phone while the agent remote-controls Sheets or Excel on a machine with full keyboard and mouse precision.
AI agents shine whenever a task is repetitive, precise, and cross-application – which describes multi-column work perfectly.
Here is how a Simular-style AI computer agent can help:
1) You define the workflow once:
- Open a specific Google Sheet or Excel file.
- Select defined columns (for example, A:C for IDs, F:H for campaign metrics).
- Apply consistent formatting, filters, or formulas.
- Export or copy the results to a client-facing document.
2) The agent learns by imitation
Using a platform like Simular Pro, you effectively show the agent what to click and in what order. Because every action is transparent and logged, you can review: Did it select the right columns? Did it skip anything?
3) You scale it across accounts
Once the pattern is proven, the same agent can repeat it for every client sheet or regional workbook: open file, select the right columns, update, save, and close – thousands of safe, deterministic steps.
This not only saves hours of manual selection but also reduces human error, letting business owners, agencies, and marketers focus on analysis and decisions rather than on remembering keyboard shortcuts.